Search the PBPK Model Repository

Quickly find freely available drug and population models in our PBPK model repository.

The models provided have been collated from published examples which authors have shared in our Published Model Collection or developed as part of various global health projects in our Global Health Collection. This search facility searches both model collections simultaneously.

To contribute published user compound and/or population files, upload your files here: Upload Model Files

Searching Tips

You can use a * character as a wildcard at the end of a alphanumeric search term. The search term must start with at least one character before the wildcard. E.g., Rifam* will get you “Rifampicin” and “Rifampin”.
You can also use a * character as a wildcard in the middle of a alphanumeric search term. The search term must still start with at least one character before the wildcard. E.g., Rif*in will also get you “Rifampicin” and “Rifampin” .
You can also use a * character as a wildcard at the start of a alphanumeric search term. However you must use forward slashes to delimit the search term and use a point before the wildcard. E.g., /.*picin/ will only get you “Rifampicin”.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Found 141 Matches

Tenofovir PBPK Model Review 2020

Model Files Publication

Tenofovir PBPK Model Review 2020

Search Score: 1

KoreanGeneral_Population_V15R1_SeoulNationalUniversityAndHospital_20190424

Model Files Publication

General Korean population for Simcyp.

Search Score: 1

Aripiprazole_V12R2_USFDA_20160510

Model Files Publication

Note: additional dissolution data 0.5 hr 55% not captured in the supplemental materials of the publication

Search Score: 1

Lopinavir&Ritonavir_V13R2_USFDA_20190719

Model Files Publication

Compound files from publication: Physiologically Based Pharmacokinetic Modeling for Predicting the Effect of Intrinsic and Extrinsic Factors on Darunavir or Lopinavir Exposure Coadministered With Ritonavir Wagner, C., Zhao, P., Arya, V., Mullick, C., Struble, K. and Au, S (2017). https://doi.org/10.1002/jcph.936 /PMID#: 28569994 The compound file is the final model used for simulations in combination with ritonavir (submitted to repository referencing the same article). Correction: Ritonavir's pKa 2 should be 2.6, reported in Supp. Table 1 was 2.8 https://accp1.onlinelibrary.wiley.com/doi/full/10.1002/jcph.936

Search Score: 1

Search the PBPK Model Repository

Searching Tips

Tenofovir PBPK Model Review 2020

KoreanGeneral_Population_V15R1_SeoulNationalUniversityAndHospital_20190424

Aripiprazole_V12R2_USFDA_20160510

Lopinavir&Ritonavir_V13R2_USFDA_20190719

Your Privacy