Search the PBPK Model Repository

Quickly find freely available drug and population models in our PBPK model repository.

The models provided have been collated from published examples which authors have shared in our Published Model Collection or developed as part of various global health projects in our Global Health Collection. This search facility searches both model collections simultaneously.

To contribute published user compound and/or population files, upload your files here: Upload Model Files

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You can use a * character as a wildcard at the end of a alphanumeric search term. The search term must start with at least one character before the wildcard. E.g., Rifam* will get you “Rifampicin” and “Rifampin”.
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Found 68 Matches

EsomeprazoleCapsule_V14R1_AstraZeneca_20200427

Model Files Publication

https://ascpt.onlinelibrary.wiley.com/doi/full/10.1002/cpt.905 Esomeprazole adult compound file for pediatric prediction. The following parameters need to be updated, as compared to Table 2 in the manuscript: Ka=1.331/h, tlag=1h, fu,gut=0.048

Search Score: 2

Ertugliflozin_V15R1_Pfizer_20220726

Model Files Publication

Ertugliflozin compound file, UGT1A9 and UGT2B4/7 substrate. Model developed and verified using ADME, IV PK and SD/MD clinical data. Simulated DDI with UGT inhibitor mefenamic acid. https://ascpt.onlinelibrary.wiley.com/doi/full/10.1002/psp4.12581

Search Score: 2

Emtricitabine PBPK Model Review 2020

Model Files Publication

Emtricitabine PBPK Model Review 2020

Search Score: 2

Emtricitabine_V18R1_Simcyp_20200212

Model Files Publication

https://www.ncbi.nlm.nih.gov/pubmed/31602556 FO, mainly renally excreted. Has been used for HV, Pregnancy population and elderly population.

Search Score: 2

Search the PBPK Model Repository

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EsomeprazoleCapsule_V14R1_AstraZeneca_20200427

Ertugliflozin_V15R1_Pfizer_20220726

Emtricitabine PBPK Model Review 2020

Emtricitabine_V18R1_Simcyp_20200212

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