Search the PBPK Model Repository

Quickly find freely available drug and population models in our PBPK model repository.

The models provided have been collated from published examples which authors have shared in our Published Model Collection or developed as part of various global health projects in our Global Health Collection. This search facility searches both model collections simultaneously.

To contribute published user compound and/or population files, upload your files here: Upload Model Files

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You can use a * character as a wildcard at the end of a alphanumeric search term. The search term must start with at least one character before the wildcard. E.g., Rifam* will get you “Rifampicin” and “Rifampin”.
You can also use a * character as a wildcard in the middle of a alphanumeric search term. The search term must still start with at least one character before the wildcard. E.g., Rif*in will also get you “Rifampicin” and “Rifampin” .
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Found 96 Matches

Iloperidone_V12R2_USFDA_20160510

Model Files Publication

Note/correction: predicted B/P should be 0.70, predicted Fa should be 0.84

Search Score: 1

DasabuvirRitonavirClopidogrelGlucuronide_V14R1_AbbVie_20200214

Model Files Publication

Workspace combines model files for Dasabuvir, Ritonavir, Clopidogrel and its glucuronide metabolite as published in Shebley et al., CPT, 2017 Note: The file was developed in V4R1, however the workspace cannot be open in V14R1 or V15R1, as it was last saved in V16. Therefore the fill can be opened only in Simcyp Simulator V16 and later.

Search Score: 1

Avibactam_V15R1_USFDA_20170810

Model Files Publication

http://onlinelibrary.wiley.com/doi/10.1002/cpt.750/full Avibactam compound file in healthy volunteers. Evaluation of the effect of renal impairment on PK of OAT substrates

Search Score: 1

Fostamatinib_RES_V21R1_Simcyp_20230615

Model Files Publication

Prepared: June 2023 The RES-Fostamatinib-R406_V21 model has been developed primarily as inhibitor of intestinal BCRP using the New GI physiology in Simcyp V21 with altered GI tract population inputs that became default in V22. Fostamatinib rapidly cleaved (hydrolyzed) to R406 (active moiety) in the gut by alkaline phosphatases. Thus, the Fit-for-purpose file with an in vivo CL/F is modelling the metabolite and not the parent. The verification was performed for 100-150 mg SD and BID. The Rosuvastatin DDI uses 100 mg BID. Example workspaces for the metabolite PK and the DDI with Rosuvastatin are attached. The BCRP component of Rosuvastatin (V21 using the New GI physiology) was optimised using Eltrombopag and then verified with other BCRP-Inhibitors available on the members area or within the Simcyp Simulator, see attached ‘BCRP-Inhibitor V21’ document for details.

Search Score: 1

Search the PBPK Model Repository

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Iloperidone_V12R2_USFDA_20160510

DasabuvirRitonavirClopidogrelGlucuronide_V14R1_AbbVie_20200214

Avibactam_V15R1_USFDA_20170810

Fostamatinib_RES_V21R1_Simcyp_20230615

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