Search the PBPK Model Repository

Quickly find freely available drug and population models in our PBPK model repository.

The models provided have been collated from published examples which authors have shared in our Published Model Collection or developed as part of various global health projects in our Global Health Collection. This search facility searches both model collections simultaneously.

To contribute published user compound and/or population files, upload your files here: Upload Model Files

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Found 127 Matches

Piperaquine

Model Files Publication

Brand Name(s) include: Eurartesim

Disease: Malaria

Drug Class: Antimalarials

Date Updated: January 2022

Related Files: DHA (partner in fixed dose combination)

The model at-a-glance

Absorption Model	First-Order (dose and food-dependent fa – saved in different models)
Volume of Distribution	Full PBPK (Method 2) Notes: Includes a Kp scalar and Kpadipose
Route of Elimination	CYP3A4 (80%), CYP2C9 (10%), CYP2C19 (10%)
Perpetrator DDI	CYP3A4 Inhibitor
Validation	Two clinical studies with fasted and fed groups at varying dose levels describing single and multiple dose exposure of piperaquine were used to verify the PBPK model. All of the simulated studies were within 1.5-fold of the observed values. A clinical DDI study where piperaquine was the victim of a CYP3A4-mediated DDI was accurately recovered using the PBPK model as well as a CYP3A4 perpetrator DDI with the sensitive substrate midazolam.
Limitations	Requires separate files for low and high dose due to dose-dependant fa Cmax overprediction, likely due to formulation differences Additional verification for DDIs would be ideal although studies are currently not available in literature
Updates in V19	Updated in vitrodata LogP Converted model to full PBPK with Vss predicted through Method 2

Search Score: 2

Tenofovir PBPK Model Review 2020

Model Files Publication

Tenofovir PBPK Model Review 2020

Search Score: 2

Propofol_RES_V18R1_Simcyp_20190529

Model Files Publication

Simcyp developed propofol compound file. Compound summary included. This was developed as a research file and its current status and limitations are outlined in the summary document.

Search Score: 2

Pregabalin_V14R1_AstraZeneca_20200327

Model Files Publication

Pregabalin for pediatric predictions.

Search Score: 2

Search the PBPK Model Repository

Searching Tips

Piperaquine

The model at-a-glance

Tenofovir PBPK Model Review 2020

Propofol_RES_V18R1_Simcyp_20190529

Pregabalin_V14R1_AstraZeneca_20200327

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