Search the PBPK Model Repository

Quickly find freely available drug and population models in our PBPK model repository.

The models provided have been collated from published examples which authors have shared in our Published Model Collection or developed as part of various global health projects in our Global Health Collection. This search facility searches both model collections simultaneously.

To contribute published user compound and/or population files, upload your files here: Upload Model Files

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Found 127 Matches

Ganciclovir_V15R1_USFDA_20170810

Model Files Publication

http://onlinelibrary.wiley.com/doi/10.1002/cpt.750/full Ganciclovir compound file in healthy volunteers. Evaluation of the effect of renal impairment on the PK of OAT substrates. NOTE: Kp scaler in model should be 0.33, different from Table 1.

Search Score: 1

Methotrexate_RES_V17R1_Simcyp_20180228

Model Files Publication

Simcyp developed Methotrexate compound file. Compound summary included. This was developed as a research file and its current status and limitations are outlined in summary document.

Search Score: 1

Fluoxetine&Norfluoxetine_V12R2_USFDA_20160511

Model Files Publication

Optimized, personal communication with Dr. Snoeys

Search Score: 1

Oncology_Population_V16R1_AstraZeneca_20190717

Model Files Publication

Oncology population from publication: Physiologically Based Pharmacokinetic Modeling for Olaparib Dosing Recommendations: Bridging Formulations, Drug Interactions, and Patient Populations Pilla Reddy, V., Bui, K., Scarfe, G., Zhou, D., Learoyd, M. (2018). Clinical Pharmacology and Therapeutics. https://doi.org/10.1002/cpt.1103 https://ascpt.onlinelibrary.wiley.com/doi/10.1002/cpt.1103

Search Score: 1

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Ganciclovir_V15R1_USFDA_20170810

Methotrexate_RES_V17R1_Simcyp_20180228

Fluoxetine&Norfluoxetine_V12R2_USFDA_20160511

Oncology_Population_V16R1_AstraZeneca_20190717

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