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Quickly find freely available drug and population models in our PBPK model repository.

The models provided have been collated from published examples which authors have shared in our Published Model Collection or developed as part of various global health projects in our Global Health Collection. This search facility searches both model collections simultaneously.

To contribute published user compound and/or population files, upload your files here: Upload Model Files

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Found 127 Matches

Cefuroxime_V12R1_FDA_20150709

Model Files Publication

Table 1 of main paper and further discussion in supplemental file. IV only. Key feature is the use of mechanistic kidney model to simulate the effect of severe renal impairment and probenecid inhibition.

Search Score: 1

Levocetirizine_V14R1_AstraZeneca_20200327

Model Files Publication

Levocetirizine for pediatric predictions.

Search Score: 1

ItraconazoleAndTwoMetabolites_V17R1_AstraZeneca_20191113

Model Files Publication

Capsule and solution formulation of itraconazole in different compound files. 2 Metabolites: OH-itraconazole and KETO-itraconazole. Note: If you wish to add both itraconazole metabolites then itraconazole has to be placed as substrate. https://doi.org/10.1124/dmd.118.081364

Search Score: 1

Chlorzoxazone_RES_V20R1_Simcyp_20210512

Model Files Publication

The RES-Chlorzoxazone file was primarily developed as an inhibitor of CYP3A4. This document provides: 1. Examples of model performance 2. A summary of the key pharmacokinetic features of Chlorzoxazone considered within the model.

Search Score: 1

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Cefuroxime_V12R1_FDA_20150709

Levocetirizine_V14R1_AstraZeneca_20200327

ItraconazoleAndTwoMetabolites_V17R1_AstraZeneca_20191113

Chlorzoxazone_RES_V20R1_Simcyp_20210512

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