Search the PBPK Model Repository

Quickly find freely available drug and population models in our PBPK model repository.

The models provided have been collated from published examples which authors have shared in our Published Model Collection or developed as part of various global health projects in our Global Health Collection. This search facility searches both model collections simultaneously.

To contribute published user compound and/or population files, upload your files here: Upload Model Files

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Found 127 Matches

Oseltamivir_Carboxylate_V15R1_USFDA_20170810

Model Files Publication

http://onlinelibrary.wiley.com/doi/10.1002/cpt.750/full OC model updated from Hsu 2014. Evaluation of the effect of renal impairment on the PK of OAT substrates. NOTE: logP -2.1 in the model. different from Table 1 (-2.4).

Search Score: 1

Rosuvastatin_V17R1_ASTAR_20190724

Model Files Publication

The submitted compound file for Rosuvastatin uses ADAM, Full-PBPK method 2, enzyme kinetics for metabolism and transporter kinetics for the permeability limited liver model and MechKim model. Tissue : Plasma partition coefficients have been modified to include data obtained from rat distribution studies. It has been used together with the unmodified Sim-Healthy Volunteer library file. https://www.ncbi.nlm.nih.gov/pubmed/31079160

Search Score: 1

Ranitidine_RES_V18R1_Simcyp_20190311

Model Files Publication

Simcyp developed ranitidine compound file. Compound summary included. This was developed as a research file and its current status and limitations are outlined in summary document.

Search Score: 1

Sulfasalazine_RES_V18R1_Simcyp_20190118

Model Files Publication

Simcyp developed sulfasalazine compound file. Compound summary included. This was developed as a research file and its current status and limitations are outlined in summary document.

Search Score: 1

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Oseltamivir_Carboxylate_V15R1_USFDA_20170810

Rosuvastatin_V17R1_ASTAR_20190724

Ranitidine_RES_V18R1_Simcyp_20190311

Sulfasalazine_RES_V18R1_Simcyp_20190118

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