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Quickly find freely available drug and population models in our PBPK model repository.

The models provided have been collated from published examples which authors have shared in our Published Model Collection or developed as part of various global health projects in our Global Health Collection. This search facility searches both model collections simultaneously.

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Found 7 Matches

Rofecoxib_V18R1_LongIslandUniversity_20210119
Model Files Publication
This is a compound file for rofecoxib - a mechanism based inhibitor of CYP1A2. The input values for the Rofecoxib PBPK model are listed in table 2 of the publication. The file uses a User input for fa and ka with a CV of 30% for each, a predicted fugut of 0.066 and a predicted Qgut of 16.271 L/h. Competitive CYP1A2 Inhibition with a Ki of 2.25 µM and fumic of 0.88 is also included in the file.
Search Score: 1
5HMT_V12R2_USFDA_20160510
Model Files Publication

The Budesonide compound file was evaluated in a Crohn’s Disease (CD) population (PMID: 37765205) and two workspaces are supplied to recover the pharmacokinetic profiles published by Ludin et al. in 2001 and Wilson et al., 2017. The Crohn’s disease population is based on the population presented in PMID: 36056298 (Altered Bioavailability and Pharmacokinetics in Crohn's Disease: Capturing Systems Parameters for PBPK to Assist with Predicting the Fate of Orally Administered Drugs - PubMed (nih.gov)).

Lundin, P.; Naber, T.; Nilsson, M.; Edsbäcker, S. Effect of food on the pharmacokinetics of budesonide controlled ileal release capsules in patients with active Crohn’s disease. Aliment. Pharmacol. Ther. 2001, 15, 45–51. [Google Scholar] [CrossRef]

Wilson, A.; Tirona, R.G.; Kim, R.B. CYP3A4 activity is markedly lower in patients with Crohn’s disease. Inflamm. Bowel Dis. 2017, 23, 804–813. [Google Scholar] 

 

     
     
     
Search Score: 1
Primaquine
Model Files Publication

Brand Name(s) include: Jasoprim, Malirid, Neo-Quipenyl, Pimaquin, Pmq, Primachina, Primacin, Primaquina, Primaquine, Primaquine diphosphate, Primaquine Phosphate, and Remaquin

Disease: Malaria, Plasmodium vivax, Plasmodium ovale

Drug Class: Antimalarial

Related Files: Carboxyprimaquine (metabolite)

Date Updated: March 2022

 The model at-a-glance

Absorption Model
  • First-Order

Volume of Distribution 
  • Full PBPK (Method 2)

Routes of Elimination
  • 89% MAO (entered using ‘user-UGT’ as a surrogate in the Simulator), 11% CYP2D6

Perpetrator DDI
  • CYP1A2 Inhibitor (in vitro)

Validation

  •  6 studies with single (15 to 45 mg) and multiple (15 mg QD) dosing. 100% of Cmax and AUC values within 1.5-fold.
  • No clinical DDI studies to verify contribution of metabolic routes

Limitations
  •  The active metabolites of primaquine have not characterized due to their instability. Therefore, a PBPK model for active metabolites cannot be developed in their own right.
  • Qualitative data suggests a role of P-gp, however, Jmax and Km values have not been measured.
  • There is evidence of enantiomer specific metabolism for primaquine which has not been considered in the current model.

Updates in Version 19
  • Updated in vitro protein and blood binding data and subsequent back calculation of CLint (retrograde approach)
    •  fu: 0.19 -> 0.26
    • B:P: 1 -> 0.82
  • Converted from minimal PBPK model to full PBPK model

 

Search Score: 1

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