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The models provided have been collated from published examples which authors have shared in our Published Model Collection or developed as part of various global health projects in our Global Health Collection. This search facility searches both model collections simultaneously.

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Found 95 Matches

Cycloguanil

Model Files Publication

Brand Name(s) include: N/A

Disease: Malaria

Drug Class: Antimalarials

Date Updated: March 2022

Related drugs: Proguanil

The model at-a-glance

Absorption Model	First-Order
Volume of Distribution	Full PBPK (Method 2)
Route of Elimination	Formed by CYP2C19, CYP3A4; unknown clearance mechanism
Perpetrator DDI	CYP2D6 Inhibitor
Validation	Proguanil and cycloguanil files were built using in vitro and clinical (Jeppersen et al., 1997) data 5 clinical studies describing single and multiple dose exposure of cycloguanil were used to verify the PBPK model. 60% of studies were within 2-fold, of which 40% were within 1.5-fold. A clinical DDI study where proguanil was the victim of a CYP2C19-mediated DDI was accurately recovered using the PBPK model.
Limitations	Prediction of cycloguanil exposure was complicated by not knowing the polymorphism classification of subjects in each study, hence the model performance was deemed acceptable using the criteria of being within 2-fold of observed. Verification needed for perpetrator DDI assessment as literature data is unavailable at this time
Updates in V19	Recalculated fm values using the corrected dose administered in Jeppesen et al., 1997 Previous version used paper calculation of total clearance which did not account for the weight of the salt in the 200 mg dose administered Model converted from minimal to full PBPK distribution model Updated in vitro data Updated CYP2D6 IC₅₀

Search Score: 1

Cefuroxime_V12R1_FDA_20150709

Model Files Publication

Table 1 of main paper and further discussion in supplemental file. IV only. Key feature is the use of mechanistic kidney model to simulate the effect of severe renal impairment and probenecid inhibition.

Search Score: 1

Paclitaxel_RES_V17R1_Simcyp_20180228

Model Files Publication

Simcyp developed Paclitaxel compound file. Compound summary included. This was developed as a research file and its current status and limitations are outlined in summary document.

Search Score: 1

Chlorzoxazone_RES_V20R1_Simcyp_20210512

Model Files Publication

The RES-Chlorzoxazone file was primarily developed as an inhibitor of CYP3A4. This document provides: 1. Examples of model performance 2. A summary of the key pharmacokinetic features of Chlorzoxazone considered within the model.

Search Score: 1

Search the PBPK Model Repository

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Cycloguanil

The model at-a-glance

Cefuroxime_V12R1_FDA_20150709

Paclitaxel_RES_V17R1_Simcyp_20180228

Chlorzoxazone_RES_V20R1_Simcyp_20210512

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