Search the PBPK Model Repository

Quickly find freely available drug and population models in our PBPK model repository.

The models provided have been collated from published examples which authors have shared in our Published Model Collection or developed as part of various global health projects in our Global Health Collection. This search facility searches both model collections simultaneously.

To contribute published user compound and/or population files, upload your files here: Upload Model Files

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You can use a * character as a wildcard at the end of a alphanumeric search term. The search term must start with at least one character before the wildcard. E.g., Rifam* will get you “Rifampicin” and “Rifampin”.
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Found 95 Matches

Oseltamivir_Carboxylate_V15R1_USFDA_20170810

Model Files Publication

http://onlinelibrary.wiley.com/doi/10.1002/cpt.750/full OC model updated from Hsu 2014. Evaluation of the effect of renal impairment on the PK of OAT substrates. NOTE: logP -2.1 in the model. different from Table 1 (-2.4).

Search Score: 1

Pitavastatin_V17R1_ASTAR_20190730

Model Files Publication

The submitted compound file for Pitavastatin uses ADAM, Full PBPK method 2, enzyme kinetics for metabolism and transporter kinetics for intestinal absorption, permeability limited liver model and MechKiM model. Tissue : Plasma partition coefficients have been modified to include data obtained from rat distribution studies. It has been used together with the unmodified Sim-Healthy Volunteer library file. https://www.altex.org/index.php/altex/article/view/1215

Search Score: 1

Sulfasalazine_RES_V18R1_Simcyp_20190118

Model Files Publication

Simcyp developed sulfasalazine compound file. Compound summary included. This was developed as a research file and its current status and limitations are outlined in summary document.

Search Score: 1

Fexofenadine_RES_V23R1_Simcyp_20230401

Model Files Publication

Simcyp developed fexofenadine compound file. Compound summary included. This was developed as a research file and its current status and limitations are outlined in summary document.

Search Score: 1

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Oseltamivir_Carboxylate_V15R1_USFDA_20170810

Pitavastatin_V17R1_ASTAR_20190730

Sulfasalazine_RES_V18R1_Simcyp_20190118

Fexofenadine_RES_V23R1_Simcyp_20230401

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