Search the PBPK Model Repository

Quickly find freely available drug and population models in our PBPK model repository.

The models provided have been collated from published examples which authors have shared in our Published Model Collection or developed as part of various global health projects in our Global Health Collection. This search facility searches both model collections simultaneously.

To contribute published user compound and/or population files, upload your files here: Upload Model Files

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You can use a * character as a wildcard at the end of a alphanumeric search term. The search term must start with at least one character before the wildcard. E.g., Rifam* will get you “Rifampicin” and “Rifampin”.
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Found 95 Matches

Rofecoxib_V18R1_LongIslandUniversity_20210119

Model Files Publication

This is a compound file for rofecoxib - a mechanism based inhibitor of CYP1A2. The input values for the Rofecoxib PBPK model are listed in table 2 of the publication. The file uses a User input for fa and ka with a CV of 30% for each, a predicted fugut of 0.066 and a predicted Qgut of 16.271 L/h. Competitive CYP1A2 Inhibition with a Ki of 2.25 µM and fumic of 0.88 is also included in the file.

Search Score: 2

Cobicistat PBPK Model Review 2020

Model Files Publication

Cobicistat PBPK Model Review 2020

Search Score: 2

V19 Res Boosted Atazanavir April 2021

Model Files Publication

V19 Res Boosted Atazanavir April 2021

Search Score: 2

Rosuvastatin_V17R1_ASTAR_20190724

Model Files Publication

The submitted compound file for Rosuvastatin uses ADAM, Full-PBPK method 2, enzyme kinetics for metabolism and transporter kinetics for the permeability limited liver model and MechKim model. Tissue : Plasma partition coefficients have been modified to include data obtained from rat distribution studies. It has been used together with the unmodified Sim-Healthy Volunteer library file. https://www.ncbi.nlm.nih.gov/pubmed/31079160

Search Score: 2

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Rofecoxib_V18R1_LongIslandUniversity_20210119

Cobicistat PBPK Model Review 2020

V19 Res Boosted Atazanavir April 2021

Rosuvastatin_V17R1_ASTAR_20190724

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