Search the PBPK Model Repository

Quickly find freely available drug and population models in our PBPK model repository.

The models provided have been collated from published examples which authors have shared in our Published Model Collection or developed as part of various global health projects in our Global Health Collection. This search facility searches both model collections simultaneously.

To contribute published user compound and/or population files, upload your files here: Upload Model Files

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You can use a * character as a wildcard at the end of a alphanumeric search term. The search term must start with at least one character before the wildcard. E.g., Rifam* will get you “Rifampicin” and “Rifampin”.
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Found 95 Matches

Ranitidine_RES_V18R1_Simcyp_20190311

Model Files Publication

Simcyp developed ranitidine compound file. Compound summary included. This was developed as a research file and its current status and limitations are outlined in summary document.

Search Score: 2

R-Omeprazole_V12R2_USFDA_20160714

Model Files Publication

Note: 1. fup was reported as 0.04 in our publication (http://www.ncbi.nlm.nih.gov/pubmed/24590877) without changing the cmp file (fup=0.043). 2. The compound file was developed for R-omeprazole solution 3. We also have converted V14R1 file that has been tested to generate identical results under the condition of mutual interaction with esomeprazole (Condition 2 in Table II in our publication).

Search Score: 2

Emtricitabine PBPK Model Review 2020

Model Files Publication

Emtricitabine PBPK Model Review 2020

Search Score: 2

Rosuvastatin_Itraconazole_OH-Itraconazole_V19R1_Pfizer_20210804

Model Files Publication

An optimized Rosuvastatin (V19) model was used and DDIs predominantly driven by gut BCRP inhibition are reasonably recovered. Altogether, the following inhibitors were used: Capmatinib Fenebrutinib Fostamatinib Itraconazole Zepatier The workspace represents the DDI between Rosuvastatin and Itraconazole. Link to the publication with further details: http://doi.org/10.1002/psp4.12672

Search Score: 2

Search the PBPK Model Repository

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Ranitidine_RES_V18R1_Simcyp_20190311

R-Omeprazole_V12R2_USFDA_20160714

Emtricitabine PBPK Model Review 2020

Rosuvastatin_Itraconazole_OH-Itraconazole_V19R1_Pfizer_20210804

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